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Evo 2

DNA language model at single-nucleotide resolution with 1M base-pair context

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What Evo 2 does

  • DNA language model at single-nucleotide resolution with 1M base-pair context
  • Variant effect prediction, sequence completion and genome design
  • Free hosted 40B access via NVIDIA build.nvidia.com
  • Apache 2.0 code, weights and training data open; published in Nature

Evo 2 — straight answers

What is Evo 2?

Evo 2 is listed under Science & Research AI, in the Research & Learning category on Flocci AI Tools. DNA language model at single-nucleotide resolution with 1M base-pair context. It is free, with no paid plan attached, and it lives at github.com.

Is Evo 2 free?

Evo 2 is listed as fully free — there is no paid tier attached to it in the catalog. That makes it one of the 399 entries on Flocci AI Tools with no upgrade path built in.

What can Evo 2 do?

Evo 2 does 4 things the catalog singles out: Dna language model at single-nucleotide resolution with 1m base-pair context; variant effect prediction, sequence completion and genome design; free hosted 40b access via nvidia build.nvidia.com; apache 2.0 code, weights and training data open; published in nature.

What is the best free alternative to Evo 2?

AI Scientist-v2 is the closest free alternative: it sits in the same Science & Research AI sub-category and is free. AlphaFold Server, Biomni and Boltz also start free. The full list is on the alternatives page.

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Evo 2 alternatives

Compare all alternatives →

AlphaFold Server

Science & Research AI
free
  • Free browser-based access to AlphaFold 3-class structure prediction for non-commercial research
  • Predicts structure/interactions of proteins, DNA, RNA, ligands in one model
  • Backed by the AlphaFold Protein Structure Database of 200M+ predicted structures
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Boltz

Science & Research AI
free
  • First fully open-source model to approach AlphaFold3-level structure prediction, MIT-licensed
  • Boltz-2 adds binding-affinity prediction, not just structure
  • Hostable free via community web apps (e.g. Tamarind Bio) or run locally
Visit

Chai-1 (Chai Discovery)

Science & Research AI
freemium
  • Chai-1 is free, Apache-2.0-licensed for academic and commercial use — a genuinely open structure-prediction model
  • Chai-2 (paid, enterprise) generates de novo antibodies directly from target epitopes, used by Lilly, Novartis, Pfizer
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freemiumLeaving soon
  • Autonomous AI agent that runs literature review + data analysis cycles, condensing ~6 months of research into a day per vendor
  • Publicly available via web interface and API, not an internal-only research demo
  • Generous free tier committed by Edison Scientific, the commercial spinout now running the platform
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Biomni

Science & Research AI
freeNew
  • General-purpose biomedical agent combining LLM planning with code execution
  • Integrates 150+ bioinformatics tools and 59 databases
  • Web interface so biologists can use it without coding
  • Open-source from Stanford SNAP lab
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AI Scientist-v2

Science & Research AI
freeNew
  • Agentic tree search proposes ideas, runs experiments and writes papers
  • No human-authored templates needed
  • Open code from Sakana AI
  • Requires disclosure of AI use in resulting papers
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Head-to-head comparisons

Evo 2 vs AlphaFold ServerEvo 2 vs BoltzEvo 2 vs Chai-1 (Chai Discovery)Evo 2 vs Kosmos (Edison Scientific / FutureHouse)Evo 2 vs BiomniEvo 2 vs AI Scientist-v2