Boltz

First fully open-source model to approach AlphaFold3-level structure prediction, MIT-licensed

What Boltz does

  • First fully open-source model to approach AlphaFold3-level structure prediction, MIT-licensed
  • Boltz-2 adds binding-affinity prediction, not just structure
  • Hostable free via community web apps (e.g. Tamarind Bio) or run locally

Boltz — straight answers

What is Boltz?

Boltz is listed under Science & Research AI, in the Research & Learning category on Flocci AI Tools. First fully open-source model to approach AlphaFold3-level structure prediction, MIT-licensed. It is free, with no paid plan attached, and it lives at github.com.

Is Boltz free?

Boltz is listed as fully free — there is no paid tier attached to it in the catalog. That makes it one of the 115 entries on Flocci AI Tools with no upgrade path built in.

What can Boltz do?

Boltz does 3 things the catalog singles out: First fully open-source model to approach alphafold3-level structure prediction, mit-licensed; boltz-2 adds binding-affinity prediction, not just structure; hostable free via community web apps (e.g. tamarind bio) or run locally.

What is the best free alternative to Boltz?

AlphaFold Server is the closest free alternative: it sits in the same Science & Research AI sub-category and is free. Chai-1 (Chai Discovery) and Kosmos (Edison Scientific / FutureHouse) also start free. The full list is on the alternatives page.

See the full list →

AlphaFold Server

Science & Research AI
free
  • Free browser-based access to AlphaFold 3-class structure prediction for non-commercial research
  • Predicts structure/interactions of proteins, DNA, RNA, ligands in one model
  • Backed by the AlphaFold Protein Structure Database of 200M+ predicted structures

Chai-1 (Chai Discovery)

Science & Research AI
freemium
  • Chai-1 is free, Apache-2.0-licensed for academic and commercial use — a genuinely open structure-prediction model
  • Chai-2 (paid, enterprise) generates de novo antibodies directly from target epitopes, used by Lilly, Novartis, Pfizer
freemium
  • Autonomous AI agent that runs literature review + data analysis cycles, condensing ~6 months of research into a day per vendor
  • Publicly available via web interface and API, not an internal-only research demo
  • Generous free tier committed by Edison Scientific, the commercial spinout now running the platform

Perplexity

AI Search & Answer Engines
freemium
  • Cited, real-time answers (1B+ queries/quarter)
  • Focus modes and file uploads
  • Comet browser and Spaces
  • Strong free tier

ChatGPT Search

AI Search & Answer Engines
freemium
  • Real-time web answers inside ChatGPT
  • Inline citations and follow-ups
  • Combines search with reasoning
  • Available on the free tier

Grok DeeperSearch

AI Search & Answer Engines
freemium
  • Live search across X and the open web
  • Best for breaking news and trends
  • Reasoned, sourced summaries
  • Free daily queries

Head-to-head comparisons