Boltz vs Kosmos (Edison Scientific / FutureHouse)

Boltz is free, with no paid plan attached. Kosmos (Edison Scientific / FutureHouse) is paid, with no free tier. Both are listed under Science & Research AI, so this is a like-for-like comparison. Neither is ranked above the other — Flocci carries no sponsored placement.

Boltz vs Kosmos (Edison Scientific / FutureHouse) — straight answers

Boltz vs Kosmos (Edison Scientific / FutureHouse): what is the difference?

Boltz is free, with no paid plan attached and is listed for first fully open-source model to approach AlphaFold3-level structure prediction, MIT-licensed. Kosmos (Edison Scientific / FutureHouse) is paid, with no free tier and is listed for autonomous AI agent that runs literature review + data analysis cycles, condensing ~6 months of research into a day per vendor. Both sit in Science & Research AI.

Is Boltz or Kosmos (Edison Scientific / FutureHouse) cheaper to start with?

Boltz is the cheaper starting point: it is free, with no paid plan attached, while Kosmos (Edison Scientific / FutureHouse) is paid, with no free tier. Pricing tiers here come from the catalog, not from a promotional page.

Which should I choose, Boltz or Kosmos (Edison Scientific / FutureHouse)?

Choose Boltz if you need first fully open-source model to approach AlphaFold3-level structure prediction, MIT-licensed; choose Kosmos (Edison Scientific / FutureHouse) if you need autonomous AI agent that runs literature review + data analysis cycles, condensing ~6 months of research into a day per vendor. Flocci AI Tools does not rank one above the other — it shows both feature sets side by side and lets the requirement decide.

Boltz compared with Kosmos (Edison Scientific / FutureHouse): pricing tier, category, listed capabilities and links.
 BoltzKosmos (Edison Scientific / FutureHouse)
Pricing tierFree
Free to startYesNo
CategoryResearch & LearningResearch & Learning
TypeScience & Research AIScience & Research AI
Listed capabilities
  • First fully open-source model to approach AlphaFold3-level structure prediction, MIT-licensed
  • Boltz-2 adds binding-affinity prediction, not just structure
  • Hostable free via community web apps (e.g. Tamarind Bio) or run locally
  • Autonomous AI agent that runs literature review + data analysis cycles, condensing ~6 months of research into a day per vendor
  • Publicly available via web interface and API, not an internal-only research demo
  • Kosmos itself requires a paid subscription; the free plan covers only standard agents.
Tagsboltz protein model, open source alphafold alternative, biomolecular structure prediction, boltz-2 binding affinity, open protein foldingkosmos ai scientist, futurehouse, edison scientific, autonomous research agent, ai scientific discovery agent
Websitegithub.comfuturehouse.org
Full pageBoltz details →Kosmos (Edison Scientific / FutureHouse) details →
AlternativesBoltz alternatives →Kosmos (Edison Scientific / FutureHouse) alternatives →

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